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Statins that causes diabetes

Statins are associated with an increased risk of developing diabetes. A recent large statin trial clearly linked to a significant increase statistically significant risk of developing diabetes. In this study (1), researchers conducted a meta-analysis of 13 studies of statins and found a statistically significant overall increase of 9% risk of developing diabetes. The risk of developing diabetes associated with an individual statin were: atorvastatin (Lipitor) = 14% (Zocor) = 11% of rosuvastatin (Crestor) = 18% pravastatin (Pravachol) = 3% also to a previous study, Researchers were surprised simvastatin increases the risk of developing diabetes. This study was called JUPITER (use of statins in Primary prevention: an intervention study evaluating rosuvastatin). This trial was designed to get people to go to a statin, rosuvastatin (Crestor). These two studies clearly fuel the fire of controversy about the risk / benefit of statins.
The real problem is the following: diabetes develops due to an underlying disease in the organization called insulin resistance. Obviously, it is questionable whether statins may worsen insulin resistance in some people. Possible mechanisms include: 1. Decreased physical activity due to statin induced muscle pain 2. The possible direct effect of statins on muscle to worsen insulin resistance 3. Decreased levels of vitamin D (vitamin D is synthesized from cholesterol). Low vitamin D worsening insulin resistance. Besides causing diabetes, insulin resistance also contributes to cancer progression. Diabetes is a disease in itself, disabling chronic complications such as kidney failure, blindness and amputation of the leg, just to name a few. Ironically diabetes also increases the risk of heart disease. If a statin increases your chances of developing diabetes, was really to question the overall benefits of these drugs. Especially since these drugs often cause different side effects. muscle aches and pains are common side effects, which are very debilitating for many patients. Sometimes these medications can cause serious side effects, including kidney failure and liver failure.

The essential question is: Insulin resistance is the common link between heart disease and diabetes. In addition, it also contributes to cancer progression. Why not focus on the treatment of insulin resistance: the origin of the three major diseases. Whether to go on a statin (or any other addiction for that matter) or not is ultimately a decision between doctor and patient. However, it is the responsibility of the prescribing physician, asking all the benefits and potential risks associated with drugs and let the patient make the final decision. It is a good choice!

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